Zona pellucida sperm-binding protein 3; Zona pellucida glycoprotein ZP3; Zona pellucida protein C; sperm receptor; ZP3A/ZP3B (ZP3, ZP3A, ZP3B, ZPC)

Function

• the mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction & prevents post-fertilization polyspermy, is composed of 3-4 glycoproteins, ZP1, ZP2, ZP3, & ZP4
• ZP3 is essential for sperm binding & zona matrix formation
• proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida
• polymers of ZP2 & ZP3 organized into long filaments cross-linked by ZP1 homodimers (putative)

Structure

• N-glycosylated (putative)
• O-glycosylated; removal of O-linked glycans may play a role in post-fertilization block to polyspermy
• the ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida
• belongs to the ZP domain family, ZPC subfamily
• contains 1 ZP domain

Compartment

• processed zona pellucida sperm-binding protein 3
  • secreted, extracellular space, extracellular matrix
• cell membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=3

Expression

oocytes

More general terms

• membrane protein
• receptor
• glycoprotein
• matrix protein

Database

• UniProt: http://www.uniprot.org/uniprot/P21754.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7784
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7784
• OMIM: https://mirror.omim.org/entry/182889