zona pellucida sperm-binding protein 4 (zona pellucida sperm-binding protein B, ZP4, ZPB)

Function

• one of 3-4 glycoproteins comprising zona pellucida
• ZP4 may act as a sperm receptor

Structure

• proteolytically cleaved before transmembrane segment to yield secreted ectodomain incorporated in zona pellucida
• belongs to the ZP domain family, ZPB subfamily
• contains 1 P-type domain (trefoil domain)
• contains 1 ZP domain, involved in polymerization of ZP proteins to form zona pellucida

Compartment

• cell membrane
• processed form: secreted, extracellular matrix

Expression

oocytes

More general terms

• membrane protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q12836.html