zona pellucida sperm-binding protein 1 (zona pellucida glycoprotein 1, Zp-1, ZP1)

Function

• zona pellucida glycoprotein
• ZP1 ensures structural integrity of zona pellucida
• polymers of ZP2 & ZP3 organized into long filaments cross-linked by ZP1 homodimers
• ZP domain is involved in the polymerization of ZP proteins to form the zona pellucida
• proteolytically cleaved before transmembrane segment to yield secreted ectodomain incorporated in zona pellucida

Structure

• O-glycosylated
• belongs to the ZP domain family, ZPB subfamily
• contains 1 P-type domain (trefoil domain.
  • contains 1 ZP domain

Compartment

• cell membrane
• secreted, extracellular matrix upon proteolytic cleavage

Expression

expressed in oocytes

More general terms

• membrane protein
• secreted protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/195000
• UniProt: http://www.uniprot.org/uniprot/P60852.html