flavopiridol

Indications

• relapsed chronic lymphocytic leukemia (CLL)

Dosage

• bolus flavopiridol followed by 4-hour flavopiridol infusion weekly for 3 weeks (28-day cycle)
• prophylactic dexamethasone with each flavopiridol dose
• rasburicase before the first two doses of flavopiridol to prevent tumor lysis syndrome
• pegfilgrastim with each cycle
• antimicrobial prophylaxis throughout course of treatment

Adverse effects

• most common: (all >90%)
  • neutropenia
  • diarrhea
  • fatigue
  • abnormal liver function tests
• less common
  • tumor lysis syndrome (44%),
  • cytokine release syndrome (42%)
  • infections despite prophylactic antibiotics (25%)

Mechanism of action

• cyclin-dependent kinase inhibitor

More general terms

• antineoplastic agent (chemotherapeutic agent)
• enzyme inhibitor