familial hemiplegic migraine type 3 (FHM3)

Genetics

• autosomal dominant
• associated with defects in SCN1A

Clinical manifestations

• severe subtype of migraine with aura & some degree of hemiparesis during the attacks
• variable features of nausea, vomiting, photophobia, & phonophobia
• age at onset ranges from 6 to 15 years
• occasionally associated with other neurologic symptoms, such as cerebellar ataxia or epileptic seizures
• a unique eye phenotype of elicited repetitive daily blindness has also been reported to be cosegregating with FHM3 in a single Swiss family

More general terms

• familial migraine syndrome

Database

• OMIM: https://mirror.omim.org/entry/609634