cerebellar ataxia (cerebellar syndrome, cerebellar dysmetria)
Jump to navigation
Jump to search
Etiology
- symmetric & progressive signs
- acute (days to hours)
- drugs
- acute viral cerebellitis
- postinfection syndrome
- subacute (days to weeks)
- chronic (months to years)
- acute (days to hours)
- ocal & ipsilateral cerebellar signs
- acute (hours to days)
- subacute (days to weeks)
- chronic (months to years)
- gliosis secondary to vascular lesion or demyelinating plaque
- congenital lesion
Epidemiology
- late-onset cerebellar ataxia prevalence is 1-3 per 100,000[3]
Genetics
- intronic FGF14 GAA repeat expansion in late-onset cerebellar ataxia[3]
Clinical manifestations
- gait ataxia
- poor trunk control
- incoordination or other cerebellar signs
- not much change in balance with eyes closed (negative Rhomberg test)
- late-onset cerebellar ataxia manifests after 30 years of age[3]
More general terms
More specific terms
References
- ↑ Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 2263-67
- ↑ Geriatric Review Syllabus, 7th edition Parada JT et al (eds) American Geriatrics Society, 2010
Geriatric Review Syllabus, 8th edition (GRS8) Durso SC and Sullivan GN (eds) American Geriatrics Society, 2013 - ↑ 3.0 3.1 3.2 3.3 Pellerin D et al. Deep intronic FGF14 GAA repeat expansion in late-onset cerebellar ataxia. N Engl J Med 2023 Jan 12; 388:128 PMID: https://www.ncbi.nlm.nih.gov/pubmed/36516086 https://www.nejm.org/doi/10.1056/NEJMoa2207406