deoxyribonuclease-2-alpha; acid Dnase; deoxyribonuclease II alpha; Dnase II alpha; lysosomal Dnase II; R31240-2 (DNASE2, DNASE2A, DNL2)

Function

• hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA
• plays a major role in the degradation of nuclear DNA in cellular apoptosis during development
• necessary for proper fetal development & for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells
• endonucleolytic cleavage to nucleoside 3'-phosphates & 3'-phosphooligonucleotide end-products
• glycosylated. mutations that eliminate N-glycosylation sites reduce activity, but enzymatic deglycosylation has no effect

Structure

• belongs to the Dnase II family

Compartment

lysosome

Notes

• not required for the generation of the characteristic DNA fragmentation observed in apoptotic cells
• active in degradation of DNA from necrotic cells (putative)

More general terms

• deoxyribonuclease (DNase)
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1777
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1777
• OMIM: https://mirror.omim.org/entry/126350
• UniProt: http://www.uniprot.org/uniprot/O00115.html