N-glycosylation site or Asn glycosylation site

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Introduction

Potential N-glycosylation sites are specific to the consensus sequence Asn-Xaa-Ser/Thr. The consensus tripeptide is not sufficient for N-glycosylation, because protein folding plays a role in the regulation of N-glycosylation. Pro between Asn & Ser/Thr will inhibit N-glycosylation. About 50% of the sites that have a proline C-terminal to Ser/Thr are not glycosylated.

A few glycosylation sites with the pattern Asn-Xaa-Cys are found.

↑ Textbook of Biochemistry with Clinical Correlations, 3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 750
↑ Chen C, Desmyter, L, Van Moller W, de Cabo R, Laroy W, Libert, Contreras R, Glycoprofiling of serum N-glycans: a potential aging biomarker. Aging: Mechanisms and Prevention 34th Annual Meeting of the American Aging Association June 3-6, 2005, Oakland CA