diagnostic criteria for Sjogren's syndrome

Diagnostic criteria

• ocular signs & symptoms
  • dry eyes every day for more than 3 months
  • recurrent sensation of sand or gravel in the eyes or use of tear substitutes more than 3 times/day
  • positive Schirmer's I test or rose Bengal score of >= 4 (Bijsterveld's scoring)
• oral symptoms
  • daily feeling of dry mouth for more than 3 months
  • recurrent or persistently swollen salivary glands, or use of liquids to aid in swallowing dry foods
• histopathology
  • focus score 1 in minor salivary gland biopsy
• salivary gland involvement by
  • salivary scintigraphy, or
  • parotid sialography, or
  • salivary flow (=< 1.5 mL in 15 min)
• autoantibodies to:
  • anti-SSA/Ro Ab, or
  • anti-SSB/La Ab, or
  • antinuclear antibodies (ANA)*, or
  • rheumatoid factor (RF)*

* not included as criteria in [2[

Exclusion criteria:

• previous head & neck radiation
• hepatitis C
• AIDS
• pre-existing lymphoma
• sarcoidosis
• graft-vs-host disease
• use of anticholinergic agent(s)

More general terms

• criteria

Additional terms

• Sjogren's syndrome (autoimmune epitheliitis)