hairy & enhancer of split-related protein HELT; HES/HEY-like transcription factor (HELT)

Function

• transcriptional repressor
• binds preferentially to the canonical E box sequence 5'-CACGCG-3' (putative)
• self-associates
• interacts with HES5 & HEY2

Structure

• belongs to the HEY family
• contains 1 basic helix-loop-helix (bHLH) domain
• contains 1 Orange domain

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

More general terms

• DNA-binding protein
• transcriptional silencer (transcriptional repressor)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3917
• UniProt: http://www.uniprot.org/uniprot/A6NFD8.html