transcription initiation factor IIA subunit 1; general transcription factor IIA subunit 1; TFIIAL; transcription initiation factor TFIIA 42 kD subunit; TFIIA-42; contains: transcription initiation factor IIA alpha chain; TFIIA p35 subunit; transcription initiation factor IIA beta chain; TFIIA p19 subunit (GTF2A1, TF2A1)

Function

• component of TFIIA
• TFIIA-alpha & TFIIA-beta derived from same gene transcript
• alpha & beta subunits are postranslationally produced from the precursor form by TASP1
• the cleavage promotes proteosomal degradation

Structure

• TFIIA is a heterodimer of the large unprocessed subunit 1 & a small subunit gamma
• originally believed to be a heterotrimer of an alpha (p35), a beta (p19) & a gamma subunit (p12)
• belongs to the TFIIA subunit 1 family

Compartment

nucleus

Alternative initiation

named isoforms=2

More general terms

• transcription factor IIA subunit
• phosphoprotein

More specific terms

• transcription initiation factor IIA alpha (TFIIA-alpha, TFIIA p35 subunit)
• transcription initiation factor IIA beta (TFIIA p19 subunit)

Additional terms

• TFIIA-alpha & beta-like factor; general transcription factor II A, 1-like factor (GTF2A1L, ALF, GTF2A1LF)

Component of

• transcription factor IIA

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2957
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2957
• OMIM: https://mirror.omim.org/entry/600520
• UniProt: http://www.uniprot.org/uniprot/P52655.html