transcription initiation factor IIA alpha (TFIIA-alpha, TFIIA p35 subunit)

Function

• TFIIA-alpha & TFIIA-beta derived from same gene transcript
• alpha & beta subunits are postranslationally produced from the precursor form by TASP1
• the cleavage promotes proteosomal degradation

Structure

• TFIIA is a heterodimer of the large unprocessed subunit 1 & a small subunit gamma
• originally believed to be a heterotrimer of an alpha (p35), a beta (p19) & a gamma subunit (p12)

More general terms

• transcription initiation factor IIA subunit 1

Additional terms

• TFIIA-alpha & beta-like factor; general transcription factor II A, 1-like factor (GTF2A1L, ALF, GTF2A1LF)

Component of

• transcription factor IIA

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2957
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2957
• OMIM: https://mirror.omim.org/entry/600520
• UniProt: http://www.uniprot.org/uniprot/P52655.html