dual specificity protein phosphatase 2, phosphatase of activated cells-1 (PAC-1); mitogen-induced nuclear tyrosine phosphatase
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Function
- regulates mitogenic signal transduction by dephosphorylating both Thr & Tyr residues on MAP kinases ERK1 & ERK2
- specificity for MAP kinase (s)
protein tyrosine phosphate + H2O <--> protein tyrosine + phosphate
phosphoprotein + H2O <--> protein + phosphate
Structure
- belongs to the protein-tyrosine phosphatase family non-receptor class dual specificity subfamily
- contains 1 rhodanese domain contains 1 tyrosine-protein phosphatase domain
Compartment
Expression
- expressed in hematopoietic tissues
- induced by mitogens
- transiently expressed during G1 & constitutively expressed in T-cells infected with HTLV-1
More general terms
References
- ↑ Rohan PJ, Davis P, Moskaluk CA, Kearns M, Krutzsch H, Siebenlist U, Kelly K. PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. Science. 1993 Mar 19;259(5102):1763-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7681221
- ↑ Nebreda AR. Inactivation of MAP kinases. Trends Biochem Sci. 1994 Jan;19(1):1-2. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8140614
- ↑ Ward Y, Gupta S, Jensen P, Wartmann M, Davis RJ, Kelly K. Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1. Nature. 1994 Feb 17;367(6464):651-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8107850
- ↑ UniProt http://www.uniprot.org/uniprot/Q05923.html