chromosomal translocation t(1;11)(q42.1;q14.3) (schizophrenia)

Introduction

• chromosomal translocation t(1;11)(q42.1;q14.3) involving DISC1 segregates with schizophrenia & related psychiatric disorders in a large Scottish family
  • the truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 & NDEL1

More general terms

• chromosomal translocation

Additional terms

• schizophrenia