drug interaction(s) of tizanidine with ciprofloxacin
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Drug interactions
- coadministration of tizanidine with fluvoxamine or ciprofloxacin (CYP1A2 inhibitors), increases serum concentration of tizanidine & potentiates its hypotensive & sedative effects
- no clinical studies of other CYP1A2 inhibitors on tizanidine have been done (2007)
Management
- coadministration of tizanidine with fluvoxamine, ciprofloxacin & other CYP1A2 inhibitors (zileuton, other fluoroquinolones, antiarrythmics, cimetidine, famotidine, oral contraceptives, acyclovir & ticlopidine) should be avoided