leukocytoclastic vasculitis; hypersensitivity vasculitis; trisymptome

Etiology

• autoimmune disease
  • systemic lupus erythematosus
• recent viral infection
  • hepatitis C, cryoglobulinemia
• malignancy - lymphoproliferative disorders
• drug adverse effect
• systemic vasculitis
• idiopathic (40%)

Clinical manifestations

• palpable purpura
• cutaneous vesicles, pustules, maculopapular lesions, urticaria
• occurs within 2 weeks of exposure to offending agent
• generally resolves when the offending agent is removed

Laboratory

skin biopsy

Differential diagnosis

• exanthematous drug eruption (morbilliform exanthem)

Management

• generally self-limited
  • withdrawal of offending agent
• glucocorticoids
• see acute leukocytoclastic vasculitis (Henoch-Schonlein purpura) or specific etiology

More general terms

• vasculitis
• type 3 hypersensitivity; immune complex hypersensitivity

More specific terms

• acute leukocytoclastic vasculitis (Henoch-Schonlein purpura; IgA vasculitis)
• chronic leukocytoclastic vasculitis (Gougerot-Ruiter type)
• cutaneous leukocytoclastic vasculitis
• urticarial vasculitis

Additional terms

• cryoglobulinemia (cryoglobulinemic vasculitis)
• leukocytoclasis
• serum sickness; serum sickness-like reaction