myelophthisic anemia

Etiology

• metastatic carcinoma
• lymphoproliferative malignancies
• disseminated granulomatous disease
• inherited disorders (Gaucher disease)

Pathology

• bone marrow failure secondary to infiltration by non-hematopoietic cells or pathogens
• destruction of hematopoietic precursor cells, often associated with marrow fibrosis

Clinical manifestations

• anemia
• thrombocytopenia
• neutropenia

Laboratory

• nucleated red cells, teardrop forms
• giant platelets
• immature myeloid cells in peripheral smear

More general terms

• hypoplastic anemia