7-OH-cholesterol
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Introduction
Alpha enantiomer is biologically active. Formed from cholesterol by the action of cholesterol-7-alpha hydroxylase in the rate-limiting step of bile acid synthesis.
Endogenous ligand of LXR-alpha & LXR-beta.
More general terms
Additional terms
- cytochrome P450 7A1 (CYP7A1, cholesterol-7-alpha-hydroxylase, cholesterol 7-alpha-monooxygenase)
- low density lipoprotein (LDL, beta-lipoprotein)
References
- ↑ Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):507-12. Epub 2001 Jan 9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11149950