cytochrome P450 7A1 (CYP7A1, cholesterol-7-alpha-hydroxylase, cholesterol 7-alpha-monooxygenase)
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Function
- catalyzes rate-limiting step in bile acid synthesis
- gene appears to be regulated by nuclear receptors LXR-alpha & LXR-beta
Structure
belongs to the cytochrome P450 family
Compartment
- endoplasmic reticulum membrane
- peripheral membrane, microsome membrane
More general terms
Additional terms
References
- ↑ Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):507-12. Epub 2001 Jan 9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11149950
- ↑ Wikipedia, cholesterol-7 alpha-hydroxylase entry http://en.wikipedia.org/wiki/cholesterol_7_alpha-hydroxylase