sulforaphane
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Introduction
Potent inducer of phase 2 drug metabolizing enzymes with anti-carcinogenic properties.
Occurs naturally in broccoli & brussel sprouts.
Indications
(possible uses)
- hinders growth of breast cancer cells
- induces apoptosis of colon cancer cells
- may diminish risk of macular degeneration
- may reduce risk of autism
- potentially of benefit in osteoarthritis of the knee
O=S-(CH2)4-N=C=S | CH3
Mechanism of action
- potent inducer of phase 2 drug metabolizing enzymes with anti-carcinogenic properties
- disrupts microtubules
- reduces hepatic gluconeogenesis[4]
- improves glycemic control in type 2 diabetes
More general terms
References
- ↑ Merck Index, I2th ed, Merck & Co, Rahway NJ, 1996 # 9315
- ↑ Netscape 07/14/04 sites evidence from researchers at Johns Hopkins University
- ↑ Egner PA et al Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China. Cancer Prevention Research. August 2014 7; 813 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24913818 <Internet> http://cancerpreventionresearch.aacrjournals.org/content/7/8/813
- ↑ 4.0 4.1 Axelsson AS, Tubbs E, Mecham B Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Sci Transl Med. 2017 Jun 14;9(394). PMID: https://www.ncbi.nlm.nih.gov/pubmed/28615356
- ↑ Gever J Really, Soup Might Help in Osteoarthritis? Not just any soup. And no chicken needed. MedPage Today. June 24, 2024 https://www.medpagetoday.com/rheumatology/arthritis/110794
Davidson RK, Watts L, Beasy G et al The BRoccoli In Osteoarthritis (BRIO study) - A randomised controlled feasibility trial to examine the potential protective effect of broccoli bioactives, (specifically sulforaphane), on osteoarthritis. medRxiv 2024. June 21. https://www.medrxiv.org/content/10.1101/2024.06.20.24309233v1