penicillin V (Pen-Vee K, Veetids, V-Cillin K, Aoracillin-B, Beepen VK, Lanacillin VK, Ledercillin VK, Robicillin VK, Wincillin-VK)

Introduction

Tradenames: Pen-Vee K, Veetids. 1st generation penicillin.

Indications

• moderate to severe susceptible bacterial infections
  • upper respiratory tract infections
    • pharyngitis
    • sinusitis
  • gingivostomatitis
  • skin or soft tissue infections
  • urinary tract infections
• antibiotic prophylaxis for:
  • pneumococcal infection
  • rheumatic fever
• treatment of otitis media

Dosage

• 250-500 mg PO QID
• pharyngitis alternate 1000 mg PO BID x 10 days
• Children: 25-50 mg/kg/day divided QID

Tabs: 125, 250, 500 mg.

Elixir: 125 & 250 mg/5 mL.

Antimicrobial activity

• Streptococcus pyogenes
• Staphylococcus aureus (MSSA)

Adverse effects

• common (> 10%)
  • mild diarrhea, nausea/vomiting, oral candidiasis
• uncommon (< 1%)
  • convulsions, fever, hemolytic anemia, positive direct antiglobulin (Coomb's) test (DAT), acute interstitial nephritis, hypersensitivity reactions, anaphylaxis

More general terms

• penicillin

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6869
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4731
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4730
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=121340
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=8605