tetrahydrocannabinol; delta-9-tetrahydrocannabinol; THC
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Introduction
delta-9-Tetrahydrocannabinol (THC) is an active component of marijuana.
Pharmacokinetics
- active metabolite 11-hydroxytetrahydrocannabinol
- metabolized to 11-nor-9-carboxy-delta-9-tetrahydrocannabinol
Adverse effects
- used during encoding impairs memory acquisition
- used during retrieval associated with false recognition of words & images[3]
- vitamin E acetate found in most of the tetrahydrocannabinol (THC) vaping products tested in patients with severe respiratory illness[4]
- impairs driving[5]
- dose-related dizziness & changes in thinking & perception with THC only but not THC-CBD combination
Laboratory
- tetrahydrocannabinol in hair
- tetrahydrocannabinol in blood
- tetrahydrocannabinol in gastric fluid
- tetrahydrocannabinol in meconium
- tetrahydrocannabinol in serum/plasma
- tetrahydrocannabinol in stool
- tetrahydrocannabinol in urine*
* delta-9-Tetrahydrocannabinol homologs may evade qualitative urine drug screen
Comparative biology
- a chronic low dose of delta-9 tetrahydrocannabinol may restore CB1 receptor signaling in old mice[2]
- potential effective strategy to treat age-related cognitive impairment[2]
More general terms
More specific terms
- 11-hydroxytetrahydrocannabinol; 11-hydroxy delta-9-tetrahydrocannabinol
- 11-nor-9-carboxy-delta-9-tetrahydrocannabinol
- dronabinol (Marinol)
Additional terms
Component of
References
- ↑ Hoyte CO et al. A characterization of synthetic cannabinoid exposures reported to the National Poison Data System in 2010. Ann Emerg Med 2012 Oct; 60:435. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22575211
- ↑ 2.0 2.1 2.2 Bilkei-Gorzo A, Albayram O, Draffehn A et al A chronic low dose of delta-9 tetrahydrocannabinol (THC) restores cognitive function in old mice. Nat Med. 2017 May 8. doi:http://dx.doi.org/ 10.1038/nm.4311. PMID: https://www.ncbi.nlm.nih.gov/pubmed/28481360
- ↑ 3.0 3.1 Doss MK, Weafer J, Gallo DA, de Wit H delta-9 Tetrahydrocannabinol at retrieval drives false recollection of neutral and emotional memories. Biol Psychiatry 2018 May 9; PMID: https://www.ncbi.nlm.nih.gov/pubmed/29884456 https://www.biologicalpsychiatryjournal.com/article/S0006-3223(18)31477-X/fulltext
- ↑ 4.0 4.1 FDA Safety Alert. Sept 6, 2019 Tetrahydrocannabinol (THC)-containing Vaping Products: Vaping Illnesses. https://www.fda.gov/safety/medwatch-safety-alerts-human-medical-products/tetrahydrocannabinol-thc-containing-vaping-products-vaping-illnesses
- ↑ 5.0 5.1 George J Does Cannabidiol Impair Driving? - Driving tests suggest no, unless THC is added to the mix. MedPage Today December 1, 2020 https://www.medpagetoday.com/neurology/generalneurology/89956 Arkell TR, Vinckenbosch F, Kevin RC et al Effect of Cannabidiol and delta-9-Tetrahydrocannabinol on Driving Performance. A Randomized Clinical Trial. JAMA. 2020;324(21):2177-2186. Dec 1 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33258890 PMCID: PMC7709000 Free PMC article https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2020.21218
- ↑ Velayudhan L et al. Evaluation of THC-related neuropsychiatric symptoms among adults aged 50 years and older: A systematic review and metaregression analysis. JAMA Netw Open 2021 Feb 2; 4:e2035913 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33528550 PMCID: PMC7856542 Free PMC article https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2775736