cannabinoid receptor 1; CB1; CB-R; CANN6 (CNR1, CNR)
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Function
- role in cannabinoid-induced CNS effects
- endogenous ligand is anandamide
- coupled to Gi & pertussis toxin-sensitive G protein that inhibits N-type Ca+2 channel
- isoform 2 & isoform 3 have altered ligand binding
- interacts (via C-terminus) with CNRIP1
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
cell membrane; multi-pass membrane protein
Alternative splicing
named isoforms=3
Expression
widely expressed
Pharmacology
More general terms
Additional terms
References
- ↑ Matsuda et al Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561 1990 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2165569
- ↑ Devane WA New dawn of cannabinoid pharmacology. TIPS 15:40 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8165721