rimonabant (Acomplia, Zimulti)

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Introduction

Tradename: Acomplia (withdrawn from European Market in 2009)

Indications

Dosage

5-20 mg QD

Adverse effects

Mechanism of action

More general terms

Additional terms

References

  1. Prescriber's Letter 11(11): 2004 Investigational Drug: Rimonabant (Acomplia) Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=201114&pb=PRL (subscription needed) http://www.prescribersletter.com
  2. 2.0 2.1 Journal Watch 25(12):98, 2005 Van Gaal LF, Rissanen AM, Scheen AJ, Ziegler O, Rossner S; RIO-Europe Study Group. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet. 2005 Apr 16;365(9468):1389-97. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15836887
  3. Despres JP, Golay A, Sjostrom L; Rimonabant in Obesity-Lipids Study Group. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med. 2005 Nov 17;353(20):2121-34. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16291982
  4. Prescriber's Letter 13(3): 2006 Acomplia (Rimonabant) and OTC Orlistat for Weight Loss Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=220313&pb=PRL (subscription needed) http://www.prescribersletter.com
  5. 5.0 5.1 Sheen AJ et al, Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: A randomised controlled study. Lancet 2006, 368:1660 PMID: https://www.ncbi.nlm.nih.gov/pubmed/17098084
  6. 6.0 6.1 Prescriber's Letter 14(7): 2007 (subscription needed) http://www.prescribersletter.com
  7. 7.0 7.1 7.2 Christensen R et al, Efficacy and safety of the weight-loss drug remonant: A meta- analysis of randomised trials. Lancet 2007, 370:1706 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18022033
  8. 8.0 8.1 Nissen SE et al, Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: the STRDIVARIUS randomized controlled trial. JAMA 2008, 299:1547 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18387931
  9. 9.0 9.1 9.2 Christensen R, Kristensen PK, Bartels EM, Bliddal H, Astrup A. Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials. Lancet. 2007 Nov 17;370(9600):1706-13. Review. Erratum in: Lancet. 2008 Feb 16;371(9612):558. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18022033

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