mephenytoin; methoin; methylphenylethylhydantoin (Mesantoin)
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Introduction
Tradename: Mesantoin.
Indications
- tonic-clonic seizures
- partial seizures
- partial seizures with motor symptoms
- partial complex seizures refractory to other agents
- (see phenytoin)
Dosage
- 100 mg PO BID/TID/QID[1]
- start 50-100 mg QD[2]
- increase 50-100 mg at weekly intervals
- do NOT increased dose more frequently than weekly
- average dose 200-600 mg/day
Tabs: 100 mg.
Adverse effects
- common (> 10%)
- psychiatric changes, slurred speech, trembling, constipation, nausea/vomiting, dizziness, drowsiness
- less common (1-10%)
- anorexia, weight loss, rash, headache, insomnia, leukopenia, hepatitis, increase in serum creatinine
- uncommon (< 1%)
- Stevens-Johnson syndrome or SLE-like syndrome, paresthesia, gingival hyperplasia, hypotension, bradycardia, cardiac arrhythmias, cardiovascular collapse, confusion, peripheral neuropathy, fever, ataxia, blood dyscrasia, thrombophlebitis, diplopia, nystagmus, blurred vision, lymphadenopathy, Hodgkin's disease-like syndrome, serum sickness, photophobia
- other (see phenytoin)
Drug interactions
(see phenytoin)
- drug interaction(s) anticonvulsants with anti-bacterial agents
- drug interaction(s) anticonvulsants with statins
Laboratory
More general terms
Additional terms
References
- ↑ 1.0 1.1 The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ 2.0 2.1 Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 - not on National VA formulary
- ↑ Kaiser Permanente Northern California Regional Drug Formulary, 1998