calcium acetate (PhosLo)

Introduction

Ca(OCOCH3)2

Indications

• treatment of hyperphosphatemia in renal failure
  • renal osteodystrophy
• treatment of electrolyte disorders
  • hypermagnesemia, hypocalcemia, hyperkalemia
• hypocalcemic tetany
• cardiac arrest secondary to hyperkalemia

Dosage

2 tabs PO TID after meals

Tabs: 667 mg.

Pharmacokinetics

• 20% absorbed & eliminated by the kidneys
• majority is not absorbed & is eliminated in the feces

Adverse effects

• uncommon (< 1%)
• hypercalcemia
• headache
• hypophosphatemia
• nausea/vomiting
• constipation
• abdominal pain
• thirst
• anorexia

Drug interactions

• may antagonize effects of calcium channel blockers
• may decrease absorption of tetracyclines & quinolones
• may increase toxicity of digoxin, precipitating arrhythmias

• drug interaction(s) of bisphosphonate with Ca+2

Mechanism of action

• binds dietary phosphate in the gut to form calcium phosphate
• calcium phosphate is eliminated in the feces

More general terms

• phosphate binder
• Ca+2

Component of

• calcium acetate/magnesium acetate/potassium acetate/potassium chloride/sodium acetate/sodium gluconate
• aluminum sulfate/calcium acetate
• alanine/arginine/calcium acetate/cysteine/glycerol/glycine/histidine/isoleucine/leucine/lysine/methionine/phenylalanine/potassium chloride/proline/serine/sodium acetate/sodium chloride/threonine/tryptophan/valine
• alanine/arginine/calcium acetate/cysteine/glycerol/glycine/histidine/isoleucine/leucine/lysine/methionine/phenylalanine/phosphoric acid/potassium chloride/proline/serine/sodium acetate/sodium chloride/threonine/tryptophan/valine

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6116
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=82163