sodium tetradecyl sulfate (Sotradecol, Texapon K, Niaproof 4, Obliterol)

Introduction

Tradename: Sotradecol. (tetradecyl sulfate, Na+)

Indications

• treatment of small, uncomplicated varicose veins of the lower extremities
• endoscopic sclerotherapy in the management of bleeding esophageal varices

Dosage

• 0.5-2 mL of 1% (5-20 mg) for small veins IV
• 0.5-2 mL of 3% (15-60 mg) for medium or large veins (IV)

Injection: 1% (2 mL), 3% (2 mL).

Adverse effects

• not common (1-10%)
  • headache, urticaria, mucosal lesions, nausea/vomiting, discoloration at the site of injection, pain, ulceration at the site of injection, sloughing & tissue necrosis following extravasation, pulmonary edema
• uncommon (< 1%)
  • esophageal perforation, hives, asthma

More general terms

• sclerosing agent

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5248
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=14492
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=8770