choriocarcinoma

^[1]^[2]

Pathology

germ cell neoplasm & gestational trophoblastic tumor
highly malignant tumor with high propensity to hemorrhage
microscopic pathology:
- sheets of trophoblastic cells without chorionic villi that invade surrouding tissues and vascular spaces
- cellular mixture of syncytiotrophoblast, cytotrophoblast & intermediate trophoblast
- central hemorrhage and necrosis common
- strong immunoreactivity for HCG
metastases:
- lung 80%
- vagina 30%
- pelvis 20%
- brain 10%
- liver 10%

↑ Pallais JC, McInnis M, Saylor PJ, Wu RI. Case 38-2015. N Engl J Med. 2015 Dec 10;373(24):2358-2369. A 21-Year-Old Man with Fatigue and Weight Loss PMID: https://www.ncbi.nlm.nih.gov/pubmed/26650156
↑ Gestational Trophoblastic Tumors (PDQ): Treatment http://www.cancer.gov/cancertopics/pdq/treatment/gestationaltrophoblastic/HealthProfessional