apolipoprotein-E gene
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Introduction
Basal expression of apo E is independent of LXR. LXRE enhancer element mediates lipid-inducibility of apo E gene in macrophages & adipocytes, but not hepatocytes. The apoE4 allele is associated with an increased risk of late onset Alzheimer's disease, the apoE2 allele may be protective. Cortical thickness is regions related to entorhinal cortex is lower in children & young adults with apoE4 allele.[3]
More general terms
Additional terms
References
- ↑ OMIM https://mirror.omim.org/entry/107741
- ↑ Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):507-12. Epub 2001 Jan 9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11149950 (LXRE)
- ↑ 3.0 3.1 Shaw P, Lerch JP, Pruessner JC, Taylor KN, Rose AB, Greenstein D, Clasen L, Evans A, Rapoport JL, Giedd JN. Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study. Lancet Neurol. 2007 Jun;6(6):494-500. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17509484