apolipoprotein E genotype
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Indications
- confirmation of hyperlipoproteinemia type 3
- assessment of genetic component of atherosclerosis
- evaluation of late-onset familial Alzheimer's disease
Contraindications
- APOE genotyping to predict Alzheimer disease[7]
Clinical significance
- the E2/E2 gentotype in conjunction with elevated serum cholesterol, VLDL cholesterol & triglycerides confirms diagnosis of type 3 hyperlipoproteinemia
- patients with E2/E2 & E4/E4 genotype are prone to atherosclerosis
- risk of late onset familial Alzheimer's disease (AD) is associated with the apo E4 allele
Complications
- genotyping does not appear to increase patient distress significantly[2]
- knowlege of genotype does affect symptom complaints & test performance[6]:
More general terms
Additional terms
References
- ↑ Apo E Geotyping Lab Tests Online: http://www.labtestsonline.org/understanding/analytes/apoe/glance.html
- ↑ 2.0 2.1 Green RC et al Disclosure of APOE genotype for risk of Alzheimer's disease. N Engl J Med 2009 Jul 16; 361:245. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19605829
Kane RA and Kane RL. Effect of genetic testing for risk of Alzheimer's disease. N Engl J Med 2009 Jul 16; 361:298. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19605835 - ↑ Cassidy MR et al Comparing test-specific distress of susceptibility versus deterministic genetic testing for Alzheimer's disease. Alzheimers Dement. 2008 Nov;4(6):406-13. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19012865
- ↑ Caselli RJ, Dueck AC, Osborne D, et al. Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect. N Engl J Med Jul 16 2009; 361(3):255-263. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19605830
- ↑ ARUP Consult: Apolipoprotein E Genotyping, Cardiovascular Disease Risk https://arupconsult.com/ati/apolipoprotein-e-genotyping-cardiovascular-disease-risk
- ↑ 6.0 6.1 6.2 Lineweaver TT et al. Effect of knowledge of APOE genotype on subjective and objective memory performance in healthy older adults. Am J Psychiatry 2013 Oct 30 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24170170
- ↑ 7.0 7.1 ACGM News. July 10, 2015 ACMG Provides Recommendations on Genetic Testing Through the Choosing Wisely<TM>Campaign. https://www.acmg.net/docs/ACMG_ChoosingWisely_Final.pdf
- ↑ 8.0 8.1 8.2 Geriatric Review Syllabus, 9th edition (GRS9) Medinal-Walpole A, Pacala JT, Porter JF (eds) American Geriatrics Society, 2016
Geriatric Review Syllabus, 11th edition (GRS11) Harper GM, Lyons WL, Potter JF (eds) American Geriatrics Society, 2022 - ↑ 9.0 9.1 Ward A, Crean S, Mercaldi CJ et al Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis. Neuroepidemiology. 2012;38(1):1-17. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22179327 Free Article