CREBBP (CBP) gene

Pathology

• loss of heterozygosity described in 80% of glioblastomas.
• loss of heterozygocity around CBP gene locus seen in hepatocellular carcinoma
• chromosomal translocations in acute leukemia
  • t(8;16)(p11;p13) involving CBP & MOZ
  • t(11;16)(q23;p13.3) involving CBP & MLL
  • t(10;16)(q22;p13) involving CBP & MYST4 (AML)
• mutations associated with Rubinstein Taybi syndrome

More general terms

• unclassified gene

Database

• OMIM: https://mirror.omim.org/entry/600140