connective tissue growth factor; CCN family member 2; hypertrophic chondrocyte-specific protein 24; insulin-like growth factor-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP-8 (CTGF, CCN2, HCS24 ,IGFBP8)

Function

• major connective tissue mitoattractant secreted by vascular endothelial cells
• promotes proliferation & differentiation of chondrocytes
• mediates heparin- & divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial cells & epithelial cells
• enhances fibroblast growth factor-induced DNA synthesis

Structure

• monomer
• belongs to the CCN family
• contains 1 CTCK (C-terminal cystine knot-like) domain
• contains 1 IGFBP N-terminal domain
• contains 1 TSP type-1 domain
• contains 1 VWFC domain

Compartment

• secreted, extracellular space, extracellular matrix (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in bone marrow & thymus
• also expressed one of two Wilms tumors tested

Laboratory

• connective tissue growth factor in urine

More general terms

• secreted protein
• growth factor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1490
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1490
• OMIM: https://mirror.omim.org/entry/121009
• UniProt: http://www.uniprot.org/uniprot/P29279.html