transient receptor potential cation channel subfamily A member 1 (ankyrin-like with transmembrane domains protein 1, transformation sensitive-protein p120, TRPA1, ANKTM1)

Function

• receptor-activated non-selective cation channel involved
• detection of sensations such as cold, pain or sounds perception
• cold nociception, activated by cold temperature below 17 degrees Celsius
• pain sensation triggered by mustard oil or capsaicin
• ionotropic cannabinoid receptor
• component for the mechanosensitive transduction channel of hair cells in inner ear (putative)
• uses phosphatidylinositol second messenger system (putative)
• inhibited by ruthenium red

Structure

• belongs to the transient receptor family
• contains 15 ANK repeats

Compartment

membrane

Expression

expressed at very low level

Pathology

• may be expressed at a higher level in liposarcoma cells

More general terms

• cell surface receptor
• ion channel
• transmembrane 6 protein

Database

• OMIM: https://mirror.omim.org/entry/604775
• UniProt: http://www.uniprot.org/uniprot/O75762.html