peroxidasin homolog (vascular peroxidase, melanoma-associated antigen MG50, p53-responsive gene 2 protein) (PXDN KIAA0230 MG50 PRG2 VPO)

Function

-..........-

Donor + H2O2 <--> oxidized donor + 2 H2O

Cofactor:

• binds 1 Ca+2 per subunit (putative)
• binds 1 heme B (iron-protoporphyrin IX) group covalently per subunit (putative)

Structure

• belongs to the peroxidase family, XPO subfamily
• contains 4 Ig-like C2-type domain (immunoglobulin-like)
• contains 8 LRR repeats (leucine-rich repeats)
• contains 1 VWFC domain

Compartment

secreted (putative)

Alternative splicing

• named isoforms=2
• additional isoforms seem to exist

Expression

• expressed in heart, lung, ovary, spleen, intestine & placenta > liver, colon, pancreas, kidney, thymus, skeletal muscle & prostate
• a shorter form probably lacking the signal sequence is found in testis & in EB1 cells undergoing TP53/p53-dependent apoptosis
• expressed in fetal liver & spleen
• up-regulated in apoptotic cells

Pathology

• expressed in tumors such as melanoma, breast cancer, ovarian cancer & glioblastoma

More general terms

• melanoma associated antigen (MAGE)
• enzyme
• secreted protein
• Ca+2 binding protein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7837
• OMIM: https://mirror.omim.org/entry/605158
• UniProt: http://www.uniprot.org/uniprot/Q92626.html