melanoma-associated antigen 3; MAGE-3 antigen; antigen MZ2-D; cancer/testis antigen 1.3; CT1.3 (MAGEA3, MAGE3)

Function

• unknown
• may play a role in embryonal development, tumor transformation or aspects of tumor progression
• antigen recognized on a melanoma by autologous cytolytic T-lymphocytes

Structure

contains 1 MAGE domain

Expression

• expressed in many tumors of several types, including melanoma, head & neck squamous cell carcinoma, lung carcinoma & breast carcinoma
• not expressed in normal tissues except testes & placenta
• nog expressed in kidney tumors, leukemias & lymphomas

More general terms

• melanoma associated antigen (MAGE)

Database

• UniProt: http://www.uniprot.org/uniprot/P43357.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4102
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4102
• OMIM: https://mirror.omim.org/entry/300174