noggin (NOG)

Function

• role in cartilage morphogenesis & joint formation
• inhibitor of bone morphogenetic proteins (BMP) signaling required for growth & patterning of neural tube & somite

Structure

• homodimer, disulfide-linked

Compartment

secreted

Pathology

• defects in NOG are associated with
  • symphalangism proximal syndrome
  • multiple synostoses syndrome-1
  • tarsal-carpal coalition syndrome
  • stapes ankylosis with broad thumb & toes

More general terms

• secreted protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/184460
• OMIM: https://mirror.omim.org/entry/185800
• OMIM: https://mirror.omim.org/entry/186500
• OMIM: https://mirror.omim.org/entry/186570
• OMIM: https://mirror.omim.org/entry/602991
• UniProt: http://www.uniprot.org/uniprot/Q13253.html