protein phosphatase 1E (Ca+2/calmodulin-dependent protein kinase phosphatase N, CaMKP-N, CaMKP-nucleus, CaMKN, partner of PIX 1, partner of PIX-alpha, partner of PIXA, PPM1E, CAMKN, KIAA1072, POPX1)

Function

• protein phosphatase
• inactivates multifunctional CaM kinases, including CAMK4 & CAMK2
• dephosphorylates & inactivates PAK
• role in inhibition of actin fiber stress breakdown & in morphological changes driven by TNK2/CDC42
• heterotrimer, interacts with PAX1 & ARHGEF6 (or ARHGEF7)

phosphoprotein + H2O  <--> protein + phosphate

Cofactor: binds 2 Mg+2 or Mn+2 per subunit

Structure

• belongs to the PP2C family
• contains 1 PP2C-like domain

Compartment

• nucleus, cytoplasm
• truncated form, major form, with C-terminal part missing, is mostly found in cytoplasm with less in nucleus
• full length, minor form, is found in nucleus

Alternative splicing

named isoforms=3

More general terms

• phosphoprotein phosphatase

Database

• UniProt: http://www.uniprot.org/uniprot/Q8WY54.html