tensin-like C1 domain-containing phosphatase (C1 domain-containing phosphatase & tensin homolog, C1-TEN, tensin-2, TENC1, KIAA1075, TNS2)

Function

• regulates cell motility & proliferation
• may have phosphatase activity
• diminishes AKT1 phosphorylation
• lowers AKT1 kinase activity & interferes with AKT1 signaling
• interacts with AXL

Structure

• contains 1 C2 tensin-type domain
• contains 1 phorbol-ester/DAG-type zinc finger
• contains 1 phosphatase tensin-type domain
• contains 1 SH2 domain

Compartment

• cell junction, focal adhesion, cytoplasmic side
• detected at the end of actin stress fibers

Expression

• detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle & small intestine

More general terms

• zinc finger protein
• phosphoprotein phosphatase
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/607717
• UniProt: http://www.uniprot.org/uniprot/Q63HR2.html