complement component receptor 1-like protein (complement C4b-binding protein CR-1-like protein, CR1L)

Function

• interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3)

Structure

• belongs to the receptors of complement activation (RCA) family
• contains 8 Sushi (CCP/SCR) domains

Compartment

• cytoplasm, membrane, secreted
• predominantly found in association with the membrane fraction, but also located in the cytoplasm & in the supernatant

Alternative splicing

named isoforms=2

Expression

• expressed in fetal liver & to a lesser extent in fetal spleen & thymus
• expression appears to be limited to hematopoietic & fetal lymphoid tissue

More general terms

• glycoprotein
• receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1379
• OMIM: https://mirror.omim.org/entry/605886
• UniProt: http://www.uniprot.org/uniprot/Q2VPA4.html