C-type lectin domain family 2 member D (osteoclast inhibitory lectin, lectin-like NK cell receptor, lectin-like transcript 1, LLT-1, CLEC2D, CLAX, LLT1, OCIL)

Function

• receptor for KLRB1
• protects target cells against NK cell-mediated lysis
• inhibits osteoclast formation
• inhibits bone resorption
• modulates release of interferon-gamma
• binds high molecular weight sulfated glycosaminoglycans

Structure

contains 1 C-type lectin domain

Compartment

cell membrane

Alternative splicing

named isoforms=4

Expression

• detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus & spleen

Pathology

• up-regulated by IL-1alpha & prostaglandin E2 in cultured osteogenic sarcoma cells

More general terms

• glycoprotein
• receptor
• membrane protein
• C-type lectin superfamily

Database

• OMIM: https://mirror.omim.org/entry/605659
• UniProt: http://www.uniprot.org/uniprot/Q9UHP7.html