anthrax toxin receptor 1; tumor endothelial marker 8 (ANTXR1, ATR, TEM8)
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Function
- plays a role in cell attachment & migration
- interacts with extracellular matrix proteins & with the actin cytoskeleton
- mediates adhesion of cells to type 1 collagen & gelatin, reorganization of the actin cytoskeleton & promotes cell spreading
- plays a role in the angiogenic response of cultured umbilical vein endothelial cells
- interacts with gelatin & type 1 collagen
- interacts with the actin cytoskeleton
- binds to the protective antigen (PA) of Bacillus anthracis
- binding does not occur in the presence of Ca+2
Structure
- binding to PA seems to be effected through the VWA domain belongs to the ATR family
- contains 1 VWFA domain
Compartment
- cell membrane; single-pass type 1 membrane protein
- cell projection, lamellipodium membrane, filopodium membrane
- at the membrane of lamellipodia & at the tip of actin-enriched filopodia
- colocalizes with actin at the base of lamellipodia
Alternative splicing
- named isoforms=4
- at least some isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Expression
- detected in umbilical vein endothelial cells (at protein level)
- highly expressed in tumor endothelial cells
- up-regulated in cultured angiogenic umbilical vein endothelial cells
Pathology
- defects in ANTXR1 are associated with susceptibility to infantile capillary hemangioma