zinc finger protein 42 homolog (Zfp-42, reduced expression protein 1, REX-1, hREX-1, zinc finger protein 754, ZFP42, REX1, ZNF754)

Function

• role in self-renewal property of ES cells (By similarity). May be involved in transcriptional regulation

Structure

• belongs to the krueppel C2H2-type zinc-finger protein family
• contains 4 C2H2-type zinc fingers

Compartment

nucleus

Expression

• expressed in kidney, epidermal keratinocytes, epithelial cells (prostate, bronchii & small airways of lung)
• expressed in embryonic stem cells
• down-regulation upon retinoic acid addition to F9 stem cells

Pathology

• expressed in malignant carcinoma cell lines
• expressed in other carcinoma cell lines

More general terms

• C2H2 type zinc finger protein
• transcription factor (TF)

Database

• UniProt: http://www.uniprot.org/uniprot/Q96MM3.html