transcription factor MafF (v-maf musculoaponeurotic fibrosarcoma oncogene homolog F, U-Maf, MAFF)

Function

• interacts with upstream promoter region of oxytocin receptor gene
• transcriptional enhancer in up-regulation of oxytocin receptor gene at parturition
• lacks a putative transactivation domain, thus may behave as transcriptional repressor when it dimerizes with itself
• transcriptional activator via dimerizing with other bHLH proteins, recruits them to specific DNA-binding sites.
• role in cellular stress response (putative)

Structure

• monomer & homodimer or heterodimer

Compartment

nucleus

Expression

• expressed in the term myometrium & kidney
• induced by oxidative stress
• belongs to the bZIP family, Maf subfamily
• contains 1 bZIP domain

More general terms

• DNA-binding protein
• transcription factor (TF)

Database

• OMIM: https://mirror.omim.org/entry/604877
• UniProt: http://www.uniprot.org/uniprot/Q9ULX9.html