transcription factor 20 (stromelysin 1 PDGF-responsive element-binding protein, SPRE-binding protein, nuclear factor SPBP, AR1, TCF20, KIAA0292, SPBP)

Function

• transcriptional activator/coactivator
• binds to regulatory region of MMP3, thus controls stromelysin expression
• stimulates activity of various transcriptional activators, including JUN, SP1, PAX6 & ETS1, thus a coactivator
• interacts with RNF4 & JUN

Structure

• homodimer
• contains 1 A.T hook DNA-binding domain
• contains 1 PHD-type zinc finger
  • atypical PHD domain functions as a negative modulator of cofactor binding

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in most tissues, except in ovary & prostate
• isoform 1 is exclusively expressed in brain, heart & testis
  • predominates in liver & kidney
• isoform 2 predominates in lung

More general terms

• transcription factor (TF)
• zinc finger protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/603107
• UniProt: http://www.uniprot.org/uniprot/Q9UGU0.html