CGG triplet repeat-binding protein 1 (CGG-binding protein 1, p20-CGGBP DNA-binding protein, 20 kD CGG-binding protein, CGGBP1, CGGBP)

Function

• role in regulating FMR1 promoter
• binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter
• binding is severely inhibited by complete or partial cytosine-specific DNA methylation of the binding motif

Compartment

nucleus

Expression

• ubiquitous
• highly expressed in placenta, thymus, lymph nodes, cerebellum & cerebral cortex
• low expression in other regions of the brain
• expressed in fetal brain & kidney > fetal liver & lung

More general terms

• DNA-binding protein
• transcription factor (TF)

Database

• OMIM: https://mirror.omim.org/entry/603363
• UniProt: http://www.uniprot.org/uniprot/Q9UFW8.html