RAS-responsive element-binding protein 1 (RREB-1, Raf-responsive zinc finger protein LZ321, RREB1)

Function

• transcription factor
• binds specifically to the distal RAS-responsive element (RRE) in the calcitonin gene promoter & augments the Ras/Raf- mediated transcriptional response
• role in Ras/Raf-mediated cell differentiation

Structure

• contains 4 C2H2-type zinc fingers

Compartment

nucleus

Expression

• expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas
• not found in brain

More general terms

• transcription factor (TF)
• DNA-binding protein
• C2H2 type zinc finger protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/602209
• UniProt: http://www.uniprot.org/uniprot/Q92766.html