glucocorticoid modulatory element binding protein 1; GMEB-1; parvovirus initiation factor p96; PIF p96; DNA binding protein p96PIF (GMEB1)

Function

• binds to glucocorticoid modulatory element present in the tyrosine aminotransferase promoter
• increases sensitivity to low concentrations of glucocorticoids
• interacts with glucocorticoid receptor (NR3C1) & NCOA2/TIF2
• may interact with HSP27 & CREB-binding protein
• binds also to the transferrin receptor promoter
• homodimer, & heterodimer of GMEB1 & GMEB2

Structure

contains 1 SAND domain

Compartment

nucleus. cytoplasm. Note: may be also cytoplasmic

Alternative splicing

named isoforms=2

Pathology

• essential auxiliary factor for the replication of parvoviruses
• GMEB1 & GMEB2 form the parvovirus initiator complex

More general terms

• transcription factor (TF)
• DNA-binding protein
• phosphoprotein

Additional terms

• glucocorticoid response element (GRE, glucocorticoid meodulatory element, GME hormone response element, HRE, hormone sensitive element, HSE)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10691
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10691
• OMIM: https://mirror.omim.org/entry/604409
• UniProt: http://www.uniprot.org/uniprot/Q9Y692.html