glucocorticoid modulatory element-binding protein 2; GMEB-2; DNA-binding protein p79PIF; parvovirus initiation factor p79; PIF p79 (GMEB2, KIAA1269)

Function

• binds to glucocorticoid modulatory element present in the tyrosine aminotransferase promoter
• increases sensitivity to low concentrations of glucocorticoids
• interacts with glucocorticoid receptor (NR3C1)
• may interact with CREB-binding protein
• binds also to the transferrin receptor promoter
• homodimer, & heterodimer of GMEB1 & GMEB2

Structure

contains 1 SAND domain

Compartment

nucleus, cytoplasm

Expression

• expressed in peripheral blood lymphocytes & fetal liver
• expressed preferentially in reproductive &/or developmentally important cells, such as testis, placenta, bone marrow & fetal tissues

Pathology

• essential auxiliary factor for the replication of parvoviruses
• GMEB1 & GMEB2 form the parvovirus initiator complex

More general terms

• transcription factor (TF)
• DNA-binding protein
• phosphoprotein

Additional terms

• glucocorticoid response element (GRE, glucocorticoid meodulatory element, GME hormone response element, HRE, hormone sensitive element, HSE)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26205
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26205
• OMIM: https://mirror.omim.org/entry/607451
• UniProt: http://www.uniprot.org/uniprot/Q9UKD1.html