one cut domain family member 1; hepatocyte nuclear factor 6; HNF-6; one cut homeobox 1 (ONECUT1, HNF6, HNF6A)

Function

• transcriptional activator
• binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B & TTR
• important for liver gene transcription
• binds DNA as a monomer (putative)

Structure

• belongs to the CUT homeobox family
• contains 1 CUT DNA-binding domain
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

Expression

• highly expressed in liver
• lower expression in testis & skin

More general terms

• transcription factor (TF)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3175
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3175
• OMIM: https://mirror.omim.org/entry/604164
• UniProt: http://www.uniprot.org/uniprot/Q9UBC0.html