MHC class II regulatory factor RFX1; transcription factor RFX1; regulatory factor X 1; RFX; enhancer factor C; EF-C (RFX1)

Function

• regulatory factor essential for MHC class 2 gene expression
• binds to the X boxes of MHC class 2 genes
• also binds to an inverted repeat (ENH1) required for hepatitis B virus gene expression & to the most upstream element (alpha) of the RPL30 promoter
• binds DNA as a homodimer

Structure

belongs to the RFX family

Compartment

nucleus

More general terms

• transcription factor (TF)
• DNA-binding protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5989
• OMIM: https://mirror.omim.org/entry/600006
• OMIM: https://mirror.omim.org/entry/209920
• UniProt: http://www.uniprot.org/uniprot/P22670.html